Acute kidney failure happens when your kidneys suddenly become unable to filter waste products from your blood. When your kidneys lose their filtering abilities, dangerous levels of wastes may buildup, and your blood’s chemical makeup may get out of balance.
Acute kidney failure — also referred to as acute renal failure or acute kidney injury — starts rapidly over a few hours or a few days. Acute kidney failure is most common in people who are already hospitalized, particularly in critically ill people who require intensive care.
Acute kidney failure can be fatal and needs intensive treatment. However, acute kidney failure may be reversible. If you’re otherwise in good health, you may recover normal or nearly normal kidney function.
Signs and symptoms of acute kidney failure may be inclusive of:
- Decreased urine output, although occasionally urine output remains normal
- Fluid retention, causing swelling in your legs, ankles or feet
- Shortness of breath
- Seizures or coma in severe cases
- Chest pain or pressure
Sometimes acute kidney failure causes no signs or symptoms and is detected through lab tests done for another reason..
Acute kidney failure can happens when:
- You have a condition that slows blood flow to your kidneys
- You experience direct damage to your kidneys
- Your kidneys’ urine drainage tubes (ureters) become blocked and wastes can’t leave your body through your urine
Impaired blood flow to the kidneys
Diseases and conditions that may reduce blood flow to the kidneys and lead to kidney failure include:
- Blood or fluid loss
- Blood pressure medications
- Heart attack
- Heart disease
- Liver failure
- Use of aspirin, ibuprofen (Advil, Motrin IB, others), naproxen (Aleve, others) or related drugs
- Severe allergic reaction (anaphylaxis)
- Severe burns
- Severe dehydration
Damage to the kidneys
These diseases, conditions and agents may damage the kidneys and result to acute kidney failure:
- Blood clots in the veins and arteries in and around the kidneys
- Cholesterol deposits that block blood flow in the kidneys
- Glomerulonephritis (gloe-mer-u-loe-nuh-FRY-tis), inflammation of the tiny filters in the kidneys (glomeruli)
- Hemolytic uremic syndrome, a condition that results from premature destruction of red blood cells
- Lupus, an immune system disorder causing glomerulonephritis
- Medications, such as certain chemotherapy drugs, antibiotics, dyes used during imaging tests and zoledronic acid (Reclast, Zometa), used to treat osteoporosis and high blood calcium levels (hypercalcemia)
- Multiple myeloma, a cancer of the plasma cells
- Scleroderma, a group of rare diseases affecting the skin and connective tissues
- Thrombotic thrombocytopenic purpura, a rare blood disorder
- Toxins, such as alcohol, heavy metals and cocaine
- Vasculitis, an inflammation of blood vessels
Urine blockage in the kidneys
Diseases and conditions that could block the passage of urine out of the body (urinary obstructions) and can result to acute kidney failure include:
- Bladder cancer
- Blood clots in the urinary tract
- Cervical cancer
- Colon cancer
- Enlarged prostate
- Kidney stones
- Nerve damage involving the nerves that control the bladder
- Prostate cancer
Acute kidney failure almost always happen in connection with another medical condition or event. Conditions that can increase your risk of acute kidney failure include:
- Being hospitalized, especially for a serious condition that needs intensive care
- Advanced age
- Blockages in the blood vessels in your arms or legs (peripheral artery disease)
- High blood pressure
- Heart failure
- Kidney diseases
- Liver diseases
Potential complications of acute kidney failure include:
- Fluid buildup.Acute kidney failure may result in a buildup of fluid in your lungs, which can cause shortness of breath.
- Chest pain.If the lining that covers your heart (pericardium) becomes inflamed, you may experience chest pain.
- Muscle weakness.When your body’s fluids and electrolytes — your body’s blood chemistry — are out of balance, muscle weakness can result. Increased levels of potassium in your blood are particularly dangerous.
- Permanent kidney damage.Occasionally, acute kidney failure causes permanent loss of kidney function, or end-stage renal disease. People with end-stage renal disease require either permanent dialysis — a mechanical filtration process used to take out toxins and wastes from the body — or a kidney transplant to survive.
- Acute kidney failure can lead to loss of kidney function and, ultimately, death. The risk of death is higher in people who had kidney problems before acute kidney failure.